Talk with your doctor if this medication stops working well. Though it helps many people, this medication may sometimes cause addiction. Take this medication exactly as prescribed to lower the risk of addiction. Ask your doctor or pharmacist for more details. Upset stomach, nausea, vomiting, constipation, dizziness, lightheadedness, or drowsiness may occur. If any of these effects persist or worsen, tell your doctor or pharmacist promptly.
To prevent constipation, eat dietary fiber, drink enough water, and exercise. You may also need to take a laxative. Ask your pharmacist which type of laxative is right for you. To reduce the risk of dizziness and lightheadedness, get up slowly when rising from a sitting or lying position. Remember that your doctor has prescribed this medication because he or she has judged that the benefit to you is greater than the risk of side effects. Many people using this medication do not have serious side effects.
Stop taking this medication and get medical help right away if any of these very serious side effects occur:. This drug may rarely cause serious, possibly fatal, liver disease. Stop taking this medication and get medical help right away if you have any symptoms of liver damage, including:. A very serious allergic reaction to this drug is rare. However, get medical help right away if you notice any symptoms of a serious allergic reaction, including:.
This is not a complete list of possible side effects. If you notice other effects not listed above, contact your doctor or pharmacist. Call your doctor for medical advice about side effects. In Canada - Call your doctor for medical advice about side effects. You may report side effects to Health Canada at Before taking this medication, tell your doctor or pharmacist if you are allergic to ibuprofen or hydrocodone; or to aspirin or other NSAIDs such as naproxen, celecoxib ; or to other opioids such as benzhydrocodone, codeine, morphine, hydromorphone ; or if you have any other allergies.
This product may contain inactive ingredients, which can cause allergic reactions or other problems. Talk to your pharmacist for more details. Before using this medication, tell your doctor or pharmacist your medical history, especially of:. Problems are more likely to occur if you are dehydrated, have heart failure or kidney disease, are an older adult, or if you take certain medications see also Drug Interactions section.
Drink plenty of fluids as directed by your doctor to prevent dehydration and tell your doctor right away if you have a change in the amount of urine. This drug may make you dizzy or drowsy. Alcohol or marijuana cannabis can make you more dizzy or drowsy.
Do not drive, use machinery, or do anything that needs alertness until you can do it safely. Avoid alcoholic beverages. Talk to your doctor if you are using marijuana cannabis. Before having surgery, tell your doctor or dentist about all the products you use including prescription drugs, nonprescription drugs, and herbal products. This medicine may cause stomach bleeding. Daily use of alcohol and tobacco, especially when combined with this medicine, may increase your risk for stomach bleeding.
Avoid alcohol and stop smoking. Consult your doctor or pharmacist for more information. During pregnancy, this medication should be used only when clearly needed.
It may harm an unborn baby. Discuss the risks and benefits with your doctor. See also Warning section. This drug passes into breast milk and may have undesirable effects on a nursing infant.
Tell the doctor right away if your baby develops unusual sleepiness, difficulty feeding, or trouble breathing. Consult your doctor before breast-feeding. Drug interactions may change how your medications work or increase your risk for serious side effects.
This document does not contain all possible drug interactions. Do not start, stop, or change the dosage of any medicines without your doctor's approval. This medication may increase the risk of bleeding when taken with other drugs that also may cause bleeding. Examples include azole antifungals such as ketoconazole , macrolide antibiotics such as erythromycin , mifepristone, HIV medications such as ritonavir , rifamycins such as rifabutin, rifampin , certain drugs used to treat seizures such as carbamazepine, phenytoin , among others.
These drugs are similar to ibuprofen, so taking one of these drugs while also taking ibuprofen may increase your risk of side effects. However, if your doctor has directed you to take low-dose aspirin for heart attack or stroke prevention usually at dosages of milligrams a day , you should continue taking the aspirin unless your doctor instructs you otherwise. Talk to your doctor about using a different medication such as acetaminophen to treat pain. The practice of combining opioids with nonsteroidal antiinflammatory drugs is widespread in the clinical management of acute and chronic pain.
Using the mouse radiant heat tail-flick nociception model, we observed potent analgesia with hydrocodone. In contrast, ibuprofen as a single drug was inactive in this model of moderate to severe pain, perhaps reflecting its limited analgesic potential. Despite the inactivity of ibuprofen alone in this model, the inclusion of ibuprofen with hydrocodone markedly enhanced the analgesic response.
These conditions can occur without warning while you are using this medicine, especially in older adults. You should not use this medicine if you are allergic to hydrocodone or ibuprofen Advil, Motrin , or if you have:. Be sure your doctor knows if you also take stimulant medicine, opioid medicine, herbal products, or medicine for depression, mental illness, Parkinson's disease, migraine headaches, serious infections, or prevention of nausea and vomiting.
These medicines may interact with hydrocodone and cause a serious condition called serotonin syndrome.
If you use opioid medicine while you are pregnant, your baby could become dependent on the drug. This can cause life-threatening withdrawal symptoms in the baby after it is born. Babies born dependent on opioids may need medical treatment for several weeks. Taking ibuprofen during late pregnancy may cause bleeding in the mother or the baby during delivery. Follow the directions on your prescription label and read all medication guides.
Never use this medicine in larger amounts, or for longer than prescribed. Use the lowest dose that is effective in treating your condition.
Tell your doctor if you feel an increased urge to take more of this medicine. Never share opioid medicine with another person, especially someone with a history of drug abuse or addiction. Selling or giving away opioid medicine is against the law. If you need surgery, tell the surgeon ahead of time that you are using hydrocodone and ibuprofen. Store at room temperature away from moisture and heat. Keep track of your medicine. You should be aware if anyone is using it improperly or without a prescription.
Do not keep leftover opioid medication. Just one dose can cause death in someone using this medicine accidentally or improperly. Ask your pharmacist where to locate a drug take-back disposal program. If there is no take-back program, flush the unused medicine down the toilet. Since hydrocodone and ibuprofen is used for pain, you are not likely to miss a dose. Skip any missed dose if it is almost time for your next dose.
Do not use two doses at one time. Seek emergency medical attention or call the Poison Help line at An opioid overdose can be fatal. Overdose symptoms may include vomiting, black or bloody stools, coughing up blood, slow breathing and heart rate, severe drowsiness, muscle weakness, cold and clammy skin, pinpoint or dilated pupils, or coma.
Avoid driving or hazardous activity until you know how this medicine will affect you. Dizziness or drowsiness can cause falls, accidents, or severe injuries. They may contain ingredients similar to ibuprofen such as aspirin, ketoprofen, or naproxen. Get emergency medical help if you have signs of an allergic reaction hives, difficult breathing, swelling in your face or throat or a severe skin reaction fever, sore throat, burning in your eyes, skin pain, red or purple skin rash that spreads and causes blistering and peeling.
Get emergency medical help if you have signs of a heart attack or stroke: chest pain spreading to your jaw or shoulder, sudden numbness or weakness on one side of the body, slurred speech, leg swelling, feeling short of breath.
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